Sonos Playbar review: an excellent (and expensive) home theater addition

More Info

• Sonos Playbar: a home theater soundbar that wirelessly streams music for $699, we go hands- (and ears) on
• Sonos Playbar appears at the FCC
• Sonos for iOS adds direct device streaming, takes PCs out of the equation (hands-on)

Sonos has found a sweet spot in the audio world. Its wireless technology and ability to stream music from almost any source -- be it from the cloud or local storage -- have given it considerable geek cred, yet its simple setup still offers mass appeal. Of course, none of that would matter if its systems didn't sound good, but fortunately, Sonos' Play:3, Play:5 and its Sub have all impressed with the quality of audio they produce. The $699 Playbar is the newest member of the family, and with this product, Sonos is setting its sights squarely on the home theater market. Is it fit for your living room? Read on to find out.

Gallery: Sonos Playbar review

Filed under: Home Entertainment, HD

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/QFC8HYCYo84/

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damsel sylphlike: Reference and education articles - 4 | LearnerTalk ...

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Posted: Sat Mar 23, 2013 10:22 am?? ?Post subject: Reference and education articles - 4
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Source: http://www.learnertalk.co.uk/forum/viewtopic.php?p=108579

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Source: http://damsel-sylphlike.blogspot.com/2013/03/reference-and-education-articles-4.html

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Map of 'shortcuts' between all human genes

Mar. 18, 2013 ? Some diseases are caused by single gene mutations. Current techniques for identifying the disease-causing gene in a patient produce hundreds of potential gene candidates, making it difficult for scientists to pinpoint the single causative gene. Now, a team of researchers led by Rockefeller University scientists have created a map of gene "shortcuts" to simplify the hunt for disease-causing genes.

The investigation, spearheaded by Yuval Itan, a postdoctoral fellow in the St. Giles Laboratory of Human Genetics of Infectious Diseases, has led to the creation of what he calls the human gene connectome, the full set of distances, routes (the genes on the way), and degrees of separation, between any two human genes. Itan, a computational biologist, says the computer program he developed to generate the connectome uses the same principles that GPS navigation devices use to plan a trip between two locations. The research is reported in the online early edition of the journal Proceedings of the National Academy of Sciences.

"High throughput genome sequencing technologies generate a plethora of data, which can take months to search through," says Itan. "We believe the human gene connectome will provide a shortcut in the search for disease-causing mutations in monogenic diseases."

Itan and his colleagues, including researchers from the Necker Hospital for Sick Children, the Pasteur Institute in Paris, and Ben-Gurion University in Israel, designed applications for the use of the human gene connectome. They began with a gene called TLR3, which is important for resistance to herpes simplex encephalitis, a life-threatening infection from the herpes virus that can cause significant brain damage in genetically susceptible children. Researchers in the St. Giles lab, headed by Jean-Laurent Casanova, previously showed that children with HSE have mutations in TLR3 or in genes that are closely functionally related to TLR3. In other words, these genes are located at a short biological distance from TLR3. As a result, novel herpes simplex encephalitis-causing genes are also expected to have a short biological distance from TLR3.

To test how well the human gene connectome could predict a disease-causing gene, the researchers sequenced exomes -- all DNA of the genome that is coding for proteins -- of two patients recently shown to carry mutations of a separate gene, TBK1.

"Each patient's exome contained hundreds of genes with potentially morbid mutations," says Itan. "The challenge was to detect the single disease-causing gene." After sorting the genes by their predicted biological proximity to TLR3, Itan and his colleagues found TBK1 at the top of the list of genes in both patients. The researchers also used the TLR3 connectome -- the set of all human genes sorted by their predicted distance from TLR3 -- to successfully predict two other genes, EFGR and SRC, as part of the TLR3 pathway before they were experimentally validated, and applied other gene connectomes to detect Ehlers-Danlos syndrome and sensorineural hearing loss disease causing genes.

"The human gene connectome is, to the best of our knowledge, the only currently available prediction of the specific route and distance between any two human genes of interest, making it ideal to solve the needle in the haystack problem of detecting the single disease causing gene in a large set of potentially fatal genes," says Itan. "This can now be performed by prioritizing any number of genes by their biological distance from genes that are already known to cause the disease.

"Approaches based on the human gene connectome have the potential to significantly increase the discovery of disease-causing genes for diseases that are genetically understood in some patients as well as for those that are not well studied. The human gene connectome should also progress the general field of human genetics by predicting the nature of unknown genetic mechanisms."

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The above story is reprinted from materials provided by Rockefeller University, via Newswise.

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Journal Reference:

1. Yuval Itan, Shen-Ying Zhang, Guillaume Vogt, Avinash Abhyankar, Melina Herman, Patrick Nitschke, Dror Fried, Lluis Quintana-Murci, Laurent Abel, and Jean-Laurent Casanova. The human gene connectome as a map of short cuts for morbid allele discovery. PNAS, March 18, 2013 DOI: 10.1073/pnas.1218167110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/tlBsWkX1m-o/130318151639.htm

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Greg Carey: Rob Bell Comes Out for Marriage Equality

Recently I wrote concerning Rob Bell, the enormously popular preacher and author. I encouraged Bell to reach out to his sisters and brothers in mainline Christianity, many of whom are buying his books and other products and who have shared some of his theological sensibilities for a very long time.

This Sunday Rob Bell spoke at San Francisco's Grace Cathedral and openly endorsed marriage equality. Grace Cathedral is the Episcopal Cathedral of the Diocese of California, and I thank Julie Harris, Assistant Director of Marketing and Communications, for alerting me to his message (audio here). Bell was speaking to the Cathedral's Grace Forum in an appearance presented in partnership with his publisher, HarperCollins.

In response to a question regarding same-sex marriage, Bell said, "I am for marriage. I am for fidelity. I am for love, whether it's a man and woman, a woman and a woman, a man and a man. I think the ship has sailed and I think the church needs -- I think this is the world we are living in and we need to affirm people wherever they are."

Bell went on to say that while it used to be fair to equate evangelicals with social conservatism, that assumption no longer holds true. More pointedly, he said, "I think we are witnessing the death of a particular subculture that doesn't work. I think there is a very narrow, politically intertwined, culturally ghettoized, Evangelical subculture that was told "we're gonna change the thing" and they haven't. And they actually have turned away lots of people. And i think that when you're in a part of a subculture that is dying, you make a lot more noise because it's very painful. You sort of die or you adapt. And if you adapt, it means you have to come face to face with some of the ways we've talked about God, which don't actually shape people into more loving, compassionate people. And we have supported policies and ways of viewing the world that are actually destructive. And we've done it in the name of God and we need to repent."

When the Very Rev. Jane Shaw attempted to get Bell to take a firm position as to whether Christians "know" the truth in some ultimate sense, Bell veered in a different direction. "I would say that the powerful, revolutionary thing about Jesus' message is that he says, 'What do you do with the people that aren't like you? What do you do with the Other? What do you do with the person that's hardest to love?' . . . That's the measure of a good religion, is - you can love the people who are just like you; that's kind of easy. So what Jesus does is takes the question and talks about fruit. He's interested in what you actually produce. And that's a different discussion. How do we love the people in the world that are least like us?"

To my knowledge, Bell's interview marks the first time that he has openly supported marriage equality and perhaps the first time he has definitely separated himself from politically conservative evangelicalism.

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Follow Greg Carey on Twitter: www.twitter.com/Greg_Carey

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Source: http://www.huffingtonpost.com/greg-carey/rob-bell-comes-gay-marriage_b_2898394.html

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2 Ohio teen football players found guilty of rape

Trent Mays, 17, enters court for the fourth day of his and co-defendent defendant 16-year-old Ma'lik Richmond 's trial on rape charges in juvenile court on Saturday, March 16, 2013 in Steubenville, Ohio. Mays and Richmond are accused of raping a 16-year-old West Virginia girl in August, 2012.

Keith Srakocic, Pool, Associated Press

STEUBENVILLE, Ohio ? Two members of the high school football team that is the pride of Steubenville were found guilty Sunday of raping a drunken 16-year-old girl in a case that bitterly divided the Rust Belt city and led to accusations of a cover-up to protect the community's athletes.

Steubenville High School students Trent Mays and Ma'Lik Richmond were sentence to at least a year in juvenile jail, capping a case that came to light via a barrage of morning-after text messages, social media posts and online photos and video. Mays was sentenced to an additional year in jail on a charge of illegal use of a minor in nudity-oriented material, to be served after his rape sentence is completed.

The two teens broke down in tears after the verdict was read and later apologized to the victim and to the community. Both were emotional as they spoke, and Richmond struggled at times to talk through his sobs.

Mays, 17, and Richmond, 16, were charged with digitally penetrating the West Virginia girl, first in the back seat of a moving car after an alcohol-fueled party on Aug. 11, and then in the basement of a house. They were ordered to avoid contact with the victim until they're 21.

The case roiled the community amid allegations that more students should have been charged and led to questions about the influence of the local football team, a source of a pride in a community of 18,000 that suffered massive job losses with the collapse of the steel industry. Their arms linked, protesters stood outside the courthouse Sunday morning awaiting the verdict, some wearing masks.

The trial opened last week as a contest between prosecutors determined to show the girl was so drunk she couldn't have been a willing participant that night, and defense attorneys soliciting testimony from witnesses that would indicate that the girl, though drunk, knew what she was doing.

The teenage girl testified Saturday that she could not recall what happened the night of the attack but remembered waking up naked in a strange house after drinking at a party. The girl said she recalled drinking, leaving the party holding hands with Mays and throwing up later. When she woke up, she said she discovered her phone, earrings, shoes, and underwear were missing, she testified.

"It was really scary," she said. "I honestly did not know what to think because I could not remember anything."

The girl said she believed she was assaulted when she later read text messages among friends and saw a photo of herself taken that night, along with a video that made fun of her and the alleged attack. She said she suspected she had been drugged because she couldn't explain being as intoxicated as defense witnesses have said she was.

"They treated her like a toy," said special prosecutor Marianne Hemmeter.

Evidence introduced at the trial included graphic text messages sent by numerous students after the night of the party, including by the accuser, containing provocative descriptions of sex acts and obscene language. Lawyers noted during the trial how texts have seemed to replace talking on the phone for contemporary teens. A computer forensic expert called by the state documented tens of thousands of texts found on 17 phones seized during the investigation.

The girl herself recalled being in a car later with Mays and Richmond and asking them what happened.

"They kept telling me I was a hassle and they took care of me," she testified. "I thought I could trust him (Mays) until I saw the pictures and video."

In questioning her account, defense attorneys went after her character and credibility. Two former friends of the girl testified that the accuser had a history of drinking heavily and was known to lie.

Source: http://www.deseretnews.com/article/765624830/2-Ohio-teen-football-players-found-guilty-of-rape.html

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Berlusconi clashes with "stupid" protesters as tensions rise

ROME (Reuters) - Former Italian prime minister Silvio Berlusconi, facing trial on tax fraud and sex charges, abused protesters who whistled and jeered as he entered parliament on Saturday to vote in an election for speaker of the Senate.

"You should be ashamed, you're poor, stupid fools," he said loudly as he made his way into the Senate.

Wearing sunglasses after spending all week in hospital for eye problems, Berlusconi arrived for the final phase of the multi-round vote which is being closely watched as a pointer to the balance of power in parliament.

A few dozen protesters whistled and called out "Buffone! Buffone! (Clown)" as he made his entrance.

The 76-year-old media billionaire faces pressure over his legal problems with two trials this month as well as a separate investigation over accusations of political bribery in 2006.

On Saturday, judges granted a request to delay a hearing in his appeal against a four-year sentence for tax fraud connected with his Mediaset broadcasting empire because of the vote. The hearing will now go ahead next Saturday.

Berlusconi is also facing a separate trial in which he is charged with paying for sex with former nightclub dancer Karima el Mahroug, better known under her stage name "Ruby" when she was still a minor.

A verdict in that trial may come as early as March 25.

(Reporting By James Mackenzie; Editing by Stephen Powell)

Source: http://news.yahoo.com/berlusconi-clashes-stupid-protesters-tensions-rise-180640528.html

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Palestinians' despair grows as Obama not to ask Israel to halt settlement

RAMALLAH, March 17 (Xinhua) -- One Palestinian official said Sunday that they are more despaired after U.S. President Barack Obama said that he would not present a new Mideast peace initiative or request Israel to halt settlement activities in the Palestinian territories.

Wassel Abu Yousef, an official in Palestine Liberation Organization (PLO), told Xinhua on Sunday that "everyone should notice that the vows and stances of President Obama concerning Israeli settlement, which is the most pressing issue concerning the future of the conflict, had gone in vain."

In an interview aired on the Israeli Chanel II Television, Obama ruled out that he would ask Israel to freeze settlement construction in the Israeli settlement, adding "We had overcome the situation of preconditions." He also ruled out presenting a new initiative to push forward the stalled peace talks.

However, Obama, who will arrive in Israel on Wednesday and will hold separate meetings with Israeli and Palestinian leaders, said that Israel needed to ask herself if its settlements in the West Bank made it difficult or easy for the Palestinian moderates to get back to the negotiations table.

"It is obvious that the U.S. is not serious or interested to pressure on Israel to halt settlement. It also puts other regional issues on the top of its priority, at the expense of the Palestinian cause, something that obliged us not to count too much on this visit," said Abu Yousef.

The PLO official stressed that the Palestinian position concerning the resumption of the peace talks "is clear and firm," adding "We refuse to resume any peace negotiations with Israel before Israel halts settlement, in which the international community admitted that it is illegal."

Meanwhile, Abdul Hadi Hantash, the Palestinian expert in settlement affairs in the West Bank, told Xinhua that "When Obama' s limousine drives through the road that links between Jerusalem and Ramallah; he should open his eyes and look from the window and see how settlement had significantly grew."

"Israeli settlement occupied around 65 percent of the West Bank territory and turns its towns and cities into small isolated cantons without any geographical connection. Israeli settlement completely undermines the principle of the two-state solution that the United States is adopting," said Hantash.

Israeli settlement construction in the West Bank and around east Jerusalem was the main reason for halting the peace negotiations in October 2010. The Palestinian side halted the talks in protest of the expansion of settlement, just four weeks after Washington sponsored it.

The Palestinians said that the ongoing settlement activities on their lands are the main reason for the stalemate in the Middle East peace process. When Obama arrived in Ramallah on Thursday to meet with President Mahmoud Abbas, he would clearly notice and see how bigger Israeli settlement became.

On the adjacent Israeli settlements to the city, which can be clearly seen from the office of President Abbas, is Beit Aeil. Several weeks ago, Israeli government decided to expand it with 90 more housing units, which outraged the Palestinian leaders.

Beit Aeil is one of 144 Israeli settlements built in the West Bank and around east Jerusalem, the part of the city that was occupied by Israel since 1967. More than half a million settlers live there.

In 2009, when Obama visited Egypt and addressed his historic speech to the Muslims and Arabs from Cairo University, he called for a new start, and he reiterated that his country doesn't recognize the legitimacy of settlement and that it's time to completely halt settlement, a request rejected by Israel.

In response to the expansion of the settlement and the freeze of the peace process, the Palestinian leadership threatened of going for other diplomatic and popular actions, such as upgrading the Palestinian representation in the United Nations and intensifies the peaceful popular resistance against Israel.

An official Palestinian source, speaking on condition of anonymity, told Xinhua that the Palestinian leadership expects that Obama would exert pressure on the Palestinians not to join various UN organizations, mainly the legal ones in The Hague, in order to block any attempt to sue Israel.

Ahmed Rafqi Awad, the political science professor at Beir Zeit University in the West Bank, told Xinhua that the U.S. negligence of expanding Israeli settlement is a clear message to the Palestinians that they must live with Israeli settlements.

"Obama visits here and closes his eye before the increasing settlement in the West Bank. He doesn't want to seriously discuss it with Israel as if he wants to tell the Palestinians, 'You should accept the occupation of your lands and forget about all your legitimate rights,'" said Awad.

Source: http://english.sina.com/world/2013/0317/572288.html

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