Monday, March 25, 2013

Hand surgery enhances life quality for those with spinal cord injuries

Hand surgery enhances life quality for those with spinal cord injuries [ Back to EurekAlert! ] Public release date: 25-Mar-2013
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Contact: Johanna Wangdell
johanna.wangdell@vgregion.se
46-702-992-112
University of Gothenburg

Reconstructive hand surgery can dramatically enhance the life quality and independence of those paralysed by a cervical spinal cord injury. Despite this, the operation is not frequently performed, either in Sweden or elsewhere. Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden are now hoping to change that.

A cervical spinal cord injury entails paralysis in both arms and legs, severely limiting daily life for its victims. Previous studies have shown that the capability that those with cervical spinal cord injuries most wish to recover is a functioning hand.

At the Sahlgrenska University Hospital, since the 1970's, it has been possible to improve the gripping ability for these individuals by surgical means, and at present an estimated 40 per cent of all spinal cord injury patients in Sweden undergo this operation.

The PhD student Johanna Wangdell, who also works as an occupational therapist, has in the course of her thesis interviewed (all those) patients who have had their hand function reconstructed at the Sahlgrenska University Hospital since 2003.

The thesis shows that this hand surgery, in a dramatic way, enhances the life quality of those with spinal cord injuries:

"The surgery doesn't only deliver a physical benefit in the form of increased gripping strength. The ability to eat independently, to carry out household chores and leisure activities offers mental rewards which benefit our social life, our daily habits and the roles we perform. Knowing that you can handle things yourself, of getting back your private life and restoring your identity as active parent, for example, or the guy that can go along for a beer with his mates is, in many cases, invaluable," says Johanna Wangdell.

Besides the individual progress this represents, reconstructive hand surgery also means that the requirement for personal assistance and specially adapted housing can be reduced and this can deliver savings for society as a whole.

Despite this, the hand surgery is performed only to a very modest extent outside Sweden: whereas four out of ten victims of spinal cord injuries are operated in Sweden only one out of ten undergo the surgery in the USA.

"Few clinics in the world undertake as many operations per year of this type as the Sahlgrenska University Hospital. This means that victims of spinal cord injuries from across Europe come to the hospital for this surgery," explains Johanna Wangdell.

"This is the first study that focuses on the patient viewpoint and we can demonstrate that those who undergo this surgery experience a really high level of satisfaction. I hope that my studies will contribute to the surgery becoming available much more widely, both in Sweden and the rest of the world."

###

Contact:

Johanna Wangdell, PhD Student at the Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, and registered Occupational Therapist at the Department of Hand Surgery / Spinal Cord Injury Unit, Sahlgrenska University Hospital

Tel: + 46 31-342 92 65

Mobile: +46 702-99 21 12

johanna.wangdell@vgregion.se



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Hand surgery enhances life quality for those with spinal cord injuries [ Back to EurekAlert! ] Public release date: 25-Mar-2013
[ | E-mail | Share Share ]

Contact: Johanna Wangdell
johanna.wangdell@vgregion.se
46-702-992-112
University of Gothenburg

Reconstructive hand surgery can dramatically enhance the life quality and independence of those paralysed by a cervical spinal cord injury. Despite this, the operation is not frequently performed, either in Sweden or elsewhere. Researchers at the Sahlgrenska Academy, University of Gothenburg, Sweden are now hoping to change that.

A cervical spinal cord injury entails paralysis in both arms and legs, severely limiting daily life for its victims. Previous studies have shown that the capability that those with cervical spinal cord injuries most wish to recover is a functioning hand.

At the Sahlgrenska University Hospital, since the 1970's, it has been possible to improve the gripping ability for these individuals by surgical means, and at present an estimated 40 per cent of all spinal cord injury patients in Sweden undergo this operation.

The PhD student Johanna Wangdell, who also works as an occupational therapist, has in the course of her thesis interviewed (all those) patients who have had their hand function reconstructed at the Sahlgrenska University Hospital since 2003.

The thesis shows that this hand surgery, in a dramatic way, enhances the life quality of those with spinal cord injuries:

"The surgery doesn't only deliver a physical benefit in the form of increased gripping strength. The ability to eat independently, to carry out household chores and leisure activities offers mental rewards which benefit our social life, our daily habits and the roles we perform. Knowing that you can handle things yourself, of getting back your private life and restoring your identity as active parent, for example, or the guy that can go along for a beer with his mates is, in many cases, invaluable," says Johanna Wangdell.

Besides the individual progress this represents, reconstructive hand surgery also means that the requirement for personal assistance and specially adapted housing can be reduced and this can deliver savings for society as a whole.

Despite this, the hand surgery is performed only to a very modest extent outside Sweden: whereas four out of ten victims of spinal cord injuries are operated in Sweden only one out of ten undergo the surgery in the USA.

"Few clinics in the world undertake as many operations per year of this type as the Sahlgrenska University Hospital. This means that victims of spinal cord injuries from across Europe come to the hospital for this surgery," explains Johanna Wangdell.

"This is the first study that focuses on the patient viewpoint and we can demonstrate that those who undergo this surgery experience a really high level of satisfaction. I hope that my studies will contribute to the surgery becoming available much more widely, both in Sweden and the rest of the world."

###

Contact:

Johanna Wangdell, PhD Student at the Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, and registered Occupational Therapist at the Department of Hand Surgery / Spinal Cord Injury Unit, Sahlgrenska University Hospital

Tel: + 46 31-342 92 65

Mobile: +46 702-99 21 12

johanna.wangdell@vgregion.se



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-03/uog-hse032513.php

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Sonos Playbar review: an excellent (and expensive) home theater addition

Sonos Playbar review an excellent and expensive home theater addition

Sonos has found a sweet spot in the audio world. Its wireless technology and ability to stream music from almost any source -- be it from the cloud or local storage -- have given it considerable geek cred, yet its simple setup still offers mass appeal. Of course, none of that would matter if its systems didn't sound good, but fortunately, Sonos' Play:3, Play:5 and its Sub have all impressed with the quality of audio they produce. The $699 Playbar is the newest member of the family, and with this product, Sonos is setting its sights squarely on the home theater market. Is it fit for your living room? Read on to find out.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/QFC8HYCYo84/

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damsel sylphlike: Reference and education articles - 4 | LearnerTalk ...

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PostPosted: Sat Mar 23, 2013 10:22 am?? ?Post subject: Reference and education articles - 4 Reply with quote

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Source: http://www.learnertalk.co.uk/forum/viewtopic.php?p=108579

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Source: http://damsel-sylphlike.blogspot.com/2013/03/reference-and-education-articles-4.html

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Tuesday, March 19, 2013

Map of 'shortcuts' between all human genes

Mar. 18, 2013 ? Some diseases are caused by single gene mutations. Current techniques for identifying the disease-causing gene in a patient produce hundreds of potential gene candidates, making it difficult for scientists to pinpoint the single causative gene. Now, a team of researchers led by Rockefeller University scientists have created a map of gene "shortcuts" to simplify the hunt for disease-causing genes.

The investigation, spearheaded by Yuval Itan, a postdoctoral fellow in the St. Giles Laboratory of Human Genetics of Infectious Diseases, has led to the creation of what he calls the human gene connectome, the full set of distances, routes (the genes on the way), and degrees of separation, between any two human genes. Itan, a computational biologist, says the computer program he developed to generate the connectome uses the same principles that GPS navigation devices use to plan a trip between two locations. The research is reported in the online early edition of the journal Proceedings of the National Academy of Sciences.

"High throughput genome sequencing technologies generate a plethora of data, which can take months to search through," says Itan. "We believe the human gene connectome will provide a shortcut in the search for disease-causing mutations in monogenic diseases."

Itan and his colleagues, including researchers from the Necker Hospital for Sick Children, the Pasteur Institute in Paris, and Ben-Gurion University in Israel, designed applications for the use of the human gene connectome. They began with a gene called TLR3, which is important for resistance to herpes simplex encephalitis, a life-threatening infection from the herpes virus that can cause significant brain damage in genetically susceptible children. Researchers in the St. Giles lab, headed by Jean-Laurent Casanova, previously showed that children with HSE have mutations in TLR3 or in genes that are closely functionally related to TLR3. In other words, these genes are located at a short biological distance from TLR3. As a result, novel herpes simplex encephalitis-causing genes are also expected to have a short biological distance from TLR3.

To test how well the human gene connectome could predict a disease-causing gene, the researchers sequenced exomes -- all DNA of the genome that is coding for proteins -- of two patients recently shown to carry mutations of a separate gene, TBK1.

"Each patient's exome contained hundreds of genes with potentially morbid mutations," says Itan. "The challenge was to detect the single disease-causing gene." After sorting the genes by their predicted biological proximity to TLR3, Itan and his colleagues found TBK1 at the top of the list of genes in both patients. The researchers also used the TLR3 connectome -- the set of all human genes sorted by their predicted distance from TLR3 -- to successfully predict two other genes, EFGR and SRC, as part of the TLR3 pathway before they were experimentally validated, and applied other gene connectomes to detect Ehlers-Danlos syndrome and sensorineural hearing loss disease causing genes.

"The human gene connectome is, to the best of our knowledge, the only currently available prediction of the specific route and distance between any two human genes of interest, making it ideal to solve the needle in the haystack problem of detecting the single disease causing gene in a large set of potentially fatal genes," says Itan. "This can now be performed by prioritizing any number of genes by their biological distance from genes that are already known to cause the disease.

"Approaches based on the human gene connectome have the potential to significantly increase the discovery of disease-causing genes for diseases that are genetically understood in some patients as well as for those that are not well studied. The human gene connectome should also progress the general field of human genetics by predicting the nature of unknown genetic mechanisms."

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The above story is reprinted from materials provided by Rockefeller University, via Newswise.

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Journal Reference:

  1. Yuval Itan, Shen-Ying Zhang, Guillaume Vogt, Avinash Abhyankar, Melina Herman, Patrick Nitschke, Dror Fried, Lluis Quintana-Murci, Laurent Abel, and Jean-Laurent Casanova. The human gene connectome as a map of short cuts for morbid allele discovery. PNAS, March 18, 2013 DOI: 10.1073/pnas.1218167110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/tlBsWkX1m-o/130318151639.htm

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Greg Carey: Rob Bell Comes Out for Marriage Equality

Recently I wrote concerning Rob Bell, the enormously popular preacher and author. I encouraged Bell to reach out to his sisters and brothers in mainline Christianity, many of whom are buying his books and other products and who have shared some of his theological sensibilities for a very long time.

This Sunday Rob Bell spoke at San Francisco's Grace Cathedral and openly endorsed marriage equality. Grace Cathedral is the Episcopal Cathedral of the Diocese of California, and I thank Julie Harris, Assistant Director of Marketing and Communications, for alerting me to his message (audio here). Bell was speaking to the Cathedral's Grace Forum in an appearance presented in partnership with his publisher, HarperCollins.

In response to a question regarding same-sex marriage, Bell said, "I am for marriage. I am for fidelity. I am for love, whether it's a man and woman, a woman and a woman, a man and a man. I think the ship has sailed and I think the church needs -- I think this is the world we are living in and we need to affirm people wherever they are."

Bell went on to say that while it used to be fair to equate evangelicals with social conservatism, that assumption no longer holds true. More pointedly, he said, "I think we are witnessing the death of a particular subculture that doesn't work. I think there is a very narrow, politically intertwined, culturally ghettoized, Evangelical subculture that was told "we're gonna change the thing" and they haven't. And they actually have turned away lots of people. And i think that when you're in a part of a subculture that is dying, you make a lot more noise because it's very painful. You sort of die or you adapt. And if you adapt, it means you have to come face to face with some of the ways we've talked about God, which don't actually shape people into more loving, compassionate people. And we have supported policies and ways of viewing the world that are actually destructive. And we've done it in the name of God and we need to repent."

When the Very Rev. Jane Shaw attempted to get Bell to take a firm position as to whether Christians "know" the truth in some ultimate sense, Bell veered in a different direction. "I would say that the powerful, revolutionary thing about Jesus' message is that he says, 'What do you do with the people that aren't like you? What do you do with the Other? What do you do with the person that's hardest to love?' . . . That's the measure of a good religion, is - you can love the people who are just like you; that's kind of easy. So what Jesus does is takes the question and talks about fruit. He's interested in what you actually produce. And that's a different discussion. How do we love the people in the world that are least like us?"

To my knowledge, Bell's interview marks the first time that he has openly supported marriage equality and perhaps the first time he has definitely separated himself from politically conservative evangelicalism.

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Follow Greg Carey on Twitter: www.twitter.com/Greg_Carey

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Source: http://www.huffingtonpost.com/greg-carey/rob-bell-comes-gay-marriage_b_2898394.html

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Sunday, March 17, 2013

2 Ohio teen football players found guilty of rape

Trent Mays, 17, enters court for the fourth day of his and co-defendent defendant 16-year-old Ma'lik Richmond 's trial on rape charges in juvenile court on Saturday, March 16, 2013 in Steubenville, Ohio. Mays and Richmond are accused of raping a 16-year-old West Virginia girl in August, 2012.

Keith Srakocic, Pool, Associated Press

STEUBENVILLE, Ohio ? Two members of the high school football team that is the pride of Steubenville were found guilty Sunday of raping a drunken 16-year-old girl in a case that bitterly divided the Rust Belt city and led to accusations of a cover-up to protect the community's athletes.

Steubenville High School students Trent Mays and Ma'Lik Richmond were sentence to at least a year in juvenile jail, capping a case that came to light via a barrage of morning-after text messages, social media posts and online photos and video. Mays was sentenced to an additional year in jail on a charge of illegal use of a minor in nudity-oriented material, to be served after his rape sentence is completed.

The two teens broke down in tears after the verdict was read and later apologized to the victim and to the community. Both were emotional as they spoke, and Richmond struggled at times to talk through his sobs.

Mays, 17, and Richmond, 16, were charged with digitally penetrating the West Virginia girl, first in the back seat of a moving car after an alcohol-fueled party on Aug. 11, and then in the basement of a house. They were ordered to avoid contact with the victim until they're 21.

The case roiled the community amid allegations that more students should have been charged and led to questions about the influence of the local football team, a source of a pride in a community of 18,000 that suffered massive job losses with the collapse of the steel industry. Their arms linked, protesters stood outside the courthouse Sunday morning awaiting the verdict, some wearing masks.

The trial opened last week as a contest between prosecutors determined to show the girl was so drunk she couldn't have been a willing participant that night, and defense attorneys soliciting testimony from witnesses that would indicate that the girl, though drunk, knew what she was doing.

The teenage girl testified Saturday that she could not recall what happened the night of the attack but remembered waking up naked in a strange house after drinking at a party. The girl said she recalled drinking, leaving the party holding hands with Mays and throwing up later. When she woke up, she said she discovered her phone, earrings, shoes, and underwear were missing, she testified.

"It was really scary," she said. "I honestly did not know what to think because I could not remember anything."

The girl said she believed she was assaulted when she later read text messages among friends and saw a photo of herself taken that night, along with a video that made fun of her and the alleged attack. She said she suspected she had been drugged because she couldn't explain being as intoxicated as defense witnesses have said she was.

"They treated her like a toy," said special prosecutor Marianne Hemmeter.

Evidence introduced at the trial included graphic text messages sent by numerous students after the night of the party, including by the accuser, containing provocative descriptions of sex acts and obscene language. Lawyers noted during the trial how texts have seemed to replace talking on the phone for contemporary teens. A computer forensic expert called by the state documented tens of thousands of texts found on 17 phones seized during the investigation.

The girl herself recalled being in a car later with Mays and Richmond and asking them what happened.

"They kept telling me I was a hassle and they took care of me," she testified. "I thought I could trust him (Mays) until I saw the pictures and video."

In questioning her account, defense attorneys went after her character and credibility. Two former friends of the girl testified that the accuser had a history of drinking heavily and was known to lie.

Source: http://www.deseretnews.com/article/765624830/2-Ohio-teen-football-players-found-guilty-of-rape.html

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